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Welcome to the Portal for the Research Group of Professor Michael Holdsworth

by Michael Holdsworth last modified 02-07-2015 16:37

The University web page of Professor Michael Holdsworth is here.
How do plants survive in a hostile world? Plants cannot run away when confronted with a problem, they have to sit it out and try to survive. This means that they have evolved to respond in specific ways to different environmental changes, which provides an adaptive advantage to those that do it best.

Current areas of interest include:
  • Characterisation of the plant N-end rule pathway of targeted proteolysis.
  • Understanding the role of targeted proteolysis in sensing plant-environment interactions.
  • Gasotransmitters and gas sensing.
  • Providing molecular resources and conceptual frameworks that plant breeders and growers can use.

  • Research papers highlighting these areas:
    Guille, Sophie and Jorge presenting at Science@suttonbonington2014


    Contact us:
    Division of Plant & Crop Sciences
    University of Nottingham
    Sutton Bonington Campus
    Loughborough Leics
    LE12 5RD, UK

    Detailed instructions for reaching the campus are available.




  • Dr Guillermina Mendiondo, Barry Axcell Fellow
  • Dr Cristina Mariana Sousa Correia
  • Dr Jorge Vicente Conde
  • Dr Tinne Boeckx
  • Dr Sophie Berckhan
  • Geeta Prasad, PhD student
  • Daniel Rooney, PhD student
  • Julietta Marquez
  • Natasha Gladstone
  • Charlene Dambire
  • Closed apical hook

    The role of the N-end rule pathway of targeted proteolysis in the control of plant growth and development.

    Abbas et al. Current Biology (2015): Discovery that oxygen sensing is a component of photomorphogenesis.
    Gibbs et al. Molecular Cell (2014): Discovery of a general mechanism of nitric oxide sensing in plants.
    Gibbs et al. Nature (2011): Discovery of the mechanism of oxygen sensing in plants.
    Holman et al. PNAS (2009): First discovery of a developmental function for the N-end rule pathway in plants.


    Systems approaches to understanding the control of seed germination and seedling establishment.

    Bassel et al. PNAS (USA) (2014) 4D modelling of a germinating Arabidopsis embryo.

    Bassel et al. PNAS (USA) (2011) Genome wide network analysis of seed dormancy and germination.

    Flooded Barley

    Transfer of molecular genetic information from studies in model species, to address important agricultural problems associated with plant developmental biology and response to abiotic stress.

    Mendiondo et al. Plant Biotech. J. (2015) Making barley flood-tolerant.

    Mendiondo et al. J. Ex. Bot. (2014) The function of COMATOSE in barley.

    Work in the laboratory is funded by:


    Community Resources

    The Virtual Seed Web Resource
    This online resource provides queryable interfaces for Gene Networks associated with seed development, dormancy and germination. Users can zoom into networks, search and highlight genes of interest and download images of network representations.

    TAGGIT analysis of seed transcriptome datasets: (original reference: Carrera et al. Plant Physiology 2007): TAGGIT uses a seed germination/dormancy ontology to annotate 'omics datasets, thus allowing more biologically informed analysis. A guide and most up-to-date version (although not updated since 2009, you can also use your own gene lists) of the TAGGIT workflow.

    Thanks to the University of Nottingham MyCIB (Multidisciplinary Centre for Integrative Biology), especially Tom Gallagher, John Veasey and Alex Marshall for help setting up this portal.
    Site managed by Professor Michael Holdsworth, University of Nottingham.

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